The building was designed by Cambridge-based architecture firm Ellenzweig, which designed several other buildings on the MIT campus. MIT broke ground on Building 76 in March 2008, a topping-off ceremony was held in February 2009, and the building was dedicated on March 4, 2011. The building is located opposite the Whitehead Institute and Broad Institute and near the biology and chemical engineering buildings on the north-eastern end of MIT's campus. The 180,000 square feet (17,000 m 2) research facility is located on the corner of Main Street and Ames Street near Kendall Square in Cambridge, Massachusetts. See also: Campus of the Massachusetts Institute of Technology Notable faculty members affiliated with the Koch Institute include: The Koch Institute is affiliated with two current Nobel Laureates (Horvitz and Sharp), eighteen members of the National Academy of Sciences, eight members of the National Academy of Engineering, five National Medal of Science laureates, and ten Howard Hughes Medical Institute investigators, and one MacArthur Foundation Fellowship recipient. Koch Institute faculty teach classes at MIT, as well as train graduate and undergraduate students as well as postdoctoral fellows. The Koch Institute is home to faculty members from various departments, including Biology, Chemistry, Mechanical Engineering, and Biological Engineering more than 40 laboratories and 500 researchers across the campus. The Koch Institute has identified five areas of research that it believes are critical for controlling cancer: Developing nanotechnology-based cancer therapeutics, creating novel devices for cancer detection and monitoring, exploring the molecular and cellular basis of metastasis, advancing personalized medicine through analysis of cancer pathways and drug resistance, engineering the immune system to fight cancer. The Institute combines the existing faculty of the CCR with an equivalent number of engineering faculty to promote interdisciplinary approaches to diagnosing, monitoring, and treating cancer. Unlike many other NCI Cancer Centers, it will not provide medical care or conduct clinical research but it has partnered with oncology centers such as the Massachusetts General Hospital's Cancer Center. The Koch Institute emphasizes basic research into how cancer is caused, progresses, and responds to treatment. Half of the gift will go towards construction of the estimated $240–$280 million facility and half will pay for research, on the condition that MIT builds the center even if fund raising falls short. Koch survived a prostate cancer diagnosis in 1992, previously donated $25 million over ten years to MIT to support cancer research, and is the namesake of the university's Koch Biology Building. Koch graduated from MIT with bachelor's and master's degrees in chemical engineering and served on the university's board of directors since 1988. Koch, the executive vice president of the oil conglomerate Koch Industries. In 2007, MIT announced it had received a $100 million gift from David H. A $20 million grant was made by the Ludwig Fund, part of Ludwig Cancer Research, in November 2007 to support a Center for Molecular Oncology to be administered by the CCR. In 2006, President Susan Hockfield announced plans for a new CCR center to support and expand cancer research performed by biologists and engineers. The CCR produced four Nobel Laureates: David Baltimore (1975), Susumu Tonegawa (1987), Phillip Sharp (1993), and H. The CCR research groups were successful in identifying oncogenes, immunology of T lymphocytes, and roles of various cellular proteins. Financial support for the CCR primarily came from Center Core grant from the National Cancer Institute as well as research project grants from the National Institutes of Health, Howard Hughes Medical Institute, and foundation support. The CCR was both a physical research center as well as an organizing body for the larger MIT cancer research community of over 500 researchers. The Center researches the genetic and molecular basis of cancer, how alterations in cellular processes affect cell growth and behavior, and how the immune system develops and recognizes antigens. In 1974, the Center for Cancer Research was founded by 1969 Nobel Laureate Salvador Luria to study basic biological processes related to cancer.